Treatment of vascular headaches, classical migraine {Pizotifen}

Pizotifen Tablet: Each film-coated tablet contains Pizotifen Malate BP 0.725 mg equivalent to Pizotifen 0.50 mg

Pizotifen TS Tablet: Each film-coated Tablet contains Pizotifen Malate BP 2.175 mg equivalentto Pizotifen 1.50 mg

Pharmacology: Pizotifen is a tricyclic compound possessing structural similarities tocyproheptadine and the tricycles n antidepressants. The prophylactic effect of Pizotifen in migraine is associated with its ability to modify the humeral mechanisms of headache. It inhibits the permeability increasing effect of serotonin and histamine on the affected cranial vessels, thereby checking the transudation of plasmakinin so that the pain threshold of the receptors is maintained at normal levels. In the sequence of events leading to the migraine attack, depletion

of plasma serotonin contributes to loss of tone in the extracranial vessels. Pizotifen inhibits serotonin re-uptake by the platelets, thus maintaining plasma serotonin and preventing the loss of tone and passive diffusion of the extra cranial arteries.

Indication: Pizotifen is indicated in the Prophylactic treatment of recurrent vascular headaches, including classical migraine, common migraine and cluster headache.

Dosage and administration:

Adults: Usually 1.5 mg daily at night as a single dose or in three divided doses. Dosage should be adjusted to individual patient’s requirements up to a maximum of 4.5 mg daily. Maximum single daily dose at night 3 mg.

Children: Up to 1.5 mg daily, usually as a divided dose. Use of 1.5 mg at a time is not recommended, but up to 1 mg has been given as a single daily dose at night