Non-steroidal antiinflammatory drugs (NSAID) Diclofenac

Description:

Diclofenac Sodium is one of the most important member of non-steroidal

antiinflammatory drugs (NSAID). After taking Diclofenac, it absorbs from gastrointestinal tract and achieves peak plasma concentration within 2 hours. It inhibits the bio-synthesis of prostaglandin and thus acts as an analgesic.

Indication:

Diclofenac is indicated for Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gout,lowback pain, dental pain, post operative pain, dysmenorrhoea, biliary colic etc. and other acute musculo-skeletal disorders such as: frozen shoulder, tendonitis, teno-synovitis, bursitis, sprain, strain and dislocation.

Dosage and Administration:

1 tablet 3 times daily after meal or 1 SR Capsule once daily. In severe cases, two SR capsule may be given at 12 hour interval.

Precaution:

This type of drug should be given with caution in pregnant woman, lactating mother and those patients having a history of liver and kidney dysfunction and peptic ulcer.

Contraindication:

Diclofenac is contraindicated in patients with peptic ulcer and in patients with known hypersensitivitis to Diclofenac. Besides if asthmatic attack increases due hypersensitivity to intake of Aspirin or this type of drug, in that case the drug must be avoided.

Side effect:

Disturbance in stomach and intestine eg. epigastric pain, nausea, diarrhoea, dizziness, headache etc. may occur. Occasionally skin rash, peripheral oedema and abnormalitis of serum transaminase have been reported.