Cough Syrup contains Guaiphenesin BP 100 mg Pseudoephedrine HCl BP 30 mg and Triprolidine HCl BP 1.25 mg with expectorant action.

Description

Guaiphenesin BP 100 mg,

Pseudoephedrine HCl BP 30 mg and Triprolidine HCl BP 1.25 mg

Syrup is a mixture of expectorant, bronchodilator / decongestant and antihistamine. 

Guaiphenesin has an expectorant action and is thought to reduce sputum viscosity

 by increasing the volume and water content of the bronchial secretion, thereby

 facilitating the expectoration of sputum. Pseudoephedrine has direct and indirect

 sympathomimetic activity and is an effective upper respiratory decongestant,

 producing decongestion within 30 minutes which lasts for at least 4 hours.

 Triprolidine is a potent competitive histamine H1-receptor antagonist of the pyrrolidine group.

Syrup is absorbed from the gastrointestinal tract. Guaiphenesin is metabolised and excreted

 in the urine. Pseudoephedrine is largely excreted unchanged in the urine together with 

small amount of its hepatic metabolite and Triprolidine is metabolised in the liver

 and excreted usually as metabolites in the urine.

Indication

Guaiphenesin BP 100 mg,

Pseudoephedrine HCl BP 30 mg and Triprolidine HCl BP 1.25 mg

Syrup is a cough preparation indicated for the symptomatic relief of

upper respiratory tract disorder accompanied by productive cough which are

benefited from the administration of an antihistamine, a decongestant and an

expectorant combination

Dosage and Administration

Adult and Children over 12 years : 2 teaspoonful 3 times daily.

Children

6-12 years : 1 teaspoonful 3 times daily

2-5 years : 1/2 teaspoonful 3 times daily or as directed by the physician

Precaution  

Guaiphenesin BP 100 mg,

Pseudoephedrine HCl BP 30 mg and Triprolidine HCl BP 1.25 mg cough syrup may
cause drowsiness; so patients should not drive or

operate machineries. Concomitant use of alcohol and other centrally active durg

should be avoided. Caution should be exercised in patients with hypertension,

heart disease, diabetes, hyperthyroidism, elevated intraocular pressure and

prostatic enlargement. The drug should not be used for persistent or chronic

cough as occur with smoking, asthma or emphysema or where cough is

accompanied by excessive secretions unless directed by a physician.

Use in pregnancy : Caution should be exercised by balancing the potential

benefit of treatment of the mother against any possible hazards to the

developing foetus.

Side effect

Central nervous system depression or excitation may occur, drowsiness being

reported most frequently. Sleep disturbance and rarely hallucination have been

reported. Skin rashes with or without irritation, tachycardia, dryness of mouth,

nose and throat have occasionally been reported. Urinary retention has been

reported occasionally in man receiving Pseudoephedrine; prostatic enlargement

could have been an important predisposing factor.

Contraindication 

Guaiphenesin BP 100 mg,

Pseudoephedrine HCl BP 30 mg and Triprolidine HCl BP 1.25 mg

is contraindicated in patients with a known hypersensitivity to

Guaiphenesin, Pseudoephedrine or Triprolidine. It is contraindicated in patients

with severe hypertension or severe coronary artery disease. Also,

contraindicated in persons who are taking or have taken monoamine oxidase

inhibitors within the preceding two weeks.