Treatment of Healing of all grades of erosive esophagitis and Gastroesophageal reflux disease (GERD)

Dexlansoprazole is a proton pump inhibitor used to treat-

1. Healing of all grades of erosive esophagitis

2. Maintaining healing of erosive esophagitis

3. Heart burn associated with non-erosive Gastroesophageal reflux disease (GERD)

Dosage & administration: Dexlansoprazole capsule is administered orally. Therecommended doses of Dexlansoprazole for adults are as follows:

Indication Recommended Dose Frequency

Healing of erosive esophagitis 60 mg once daily for up to 8 weeks

Maintenance of Healed erosive esophagitis and relief of heartburn

30 mg once daily for up to 6 months Symptomatic Non-Erosive GERD 30 mg Once daily for 4 weeks

Contraindication: Dexlansoprazole is contraindicated in patients with known hypersensitivity to any component of the formulation. Hypersensitivity and anaphylaxis have been

Reported with Dexlansoprazole

Precaution: Patients taking concomitant Warfarin may require monitoring for increases in international normalized ratio (INR) and prothrombin time. Increases in INR and prothrombin time

May lead to abnormal bleeding and even death.

Side Effect: Adverse events are rarely seen; such as diarrhea, abdominal pain, nausea, vomiting, flatulence etc

Drug Interaction: Dexlansoprazole may interfere with the absorption of drugs for whichgastric pH is important for bioavailability (e.g., Ampicillin esters, Digoxin, iron salts, Ketoconazole).

Use in Pregnancy and Lactation: Dexlansoprazole is considered a pregnancy Category B medication. This means that dexlansoprazole is probably safe for use during pregnancy, although the full risks are currently unknown.

Pediatric Use: Safety and effectiveness of Dexlansoprazole in pediatric patients (less than 18 years of age) have not been established.

Geriatric Use: Safety and effectiveness of Dexlansoprazole in geriatric patients is same as Adults.

Overdose: There have been no reports of significant overdose of Dexlansoprazole. It is not expected to be removed from the circulation by hemodialysis. If an overdose occurs, treatment should be symptomatic and supportive