Dexlansoprazole
is a proton pump inhibitor used to treat-
1.
Healing of all grades of erosive esophagitis
2.
Maintaining healing of erosive esophagitis
3.
Heart burn associated with non-erosive Gastroesophageal reflux disease (GERD)
Dosage
& administration: Dexlansoprazole capsule is administered
orally. Therecommended doses of Dexlansoprazole for adults are as follows:
Indication
Recommended Dose Frequency
Healing
of erosive esophagitis 60 mg once daily for up to 8 weeks
Maintenance
of Healed erosive esophagitis and relief of heartburn
30 mg
once daily for up to 6 months Symptomatic Non-Erosive GERD 30 mg Once daily for
4 weeks
Contraindication:
Dexlansoprazole is contraindicated in patients with known hypersensitivity
to any component of the formulation. Hypersensitivity and anaphylaxis have been
Reported
with Dexlansoprazole
Precaution:
Patients taking concomitant Warfarin may require monitoring for
increases in international normalized ratio (INR) and prothrombin time.
Increases in INR and prothrombin time
May
lead to abnormal bleeding and even death.
Side
Effect: Adverse events are rarely seen; such as diarrhea,
abdominal pain, nausea, vomiting, flatulence etc
Drug
Interaction: Dexlansoprazole may interfere with the absorption
of drugs for whichgastric pH is important for bioavailability (e.g., Ampicillin
esters, Digoxin, iron salts, Ketoconazole).
Use
in Pregnancy and Lactation: Dexlansoprazole is considered
a pregnancy Category B medication. This means that dexlansoprazole is probably
safe for use during pregnancy, although the full risks are currently unknown.
Pediatric
Use: Safety and effectiveness of Dexlansoprazole in pediatric patients
(less than 18 years of age) have not been established.
Geriatric
Use: Safety and effectiveness of Dexlansoprazole in geriatric patients is
same as Adults.
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