Online Doctor Service For Health: Long time sex long time enjoy---treatment of prema...

Online Doctor Service For Health: Long time sex long time enjoy---treatment of prema...: Dapoxetine is a selective serotonin reuptake inhibitor (SSRI). The mechanism of action of Dapoxetine in premature ejaculation is pre...

Long time sex long time enjoy---treatment of premature ejaculation

Dapoxetine is a selective serotonin reuptake inhibitor (SSRI). The mechanism of action of Dapoxetine in premature ejaculation is presumed to be linked to the inhibition of neuronal reuptakeof serotonin and the subsequent potentiation of the neurotransmitter's action at preand post-synaptic receptors.

INDICATIONS

Dapoxetine is indicated for the treatment of premature ejaculation (PE) in men 18 to 64 years of age, who have one or all of the following:

>> Persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the patient wishes.

>>Marked personal distress or interpersonal difficulty as a consequence of PE.

>>Poor control over ejaculation.

DOSAGE & ADMINISTRATION

1. Starting dose is 30 mg (approximately 1 to 3 hours prior to sexual activity).

2. Maximum recommended dose is of 60 mg.

3. Maximum dosing frequency is one dose every 24 hours.

CONTRAINDICATIONS

>>Patients with known hypersensitivity to Dapoxetine hydrochloride.

>>Patients with significant pathological cardiac conditions (such as heart failure (NYHA class II-IV), conduction abnormalities (second- or third-degree AV block or sick sinus syndrome) not treated with a permanent pacemaker, significant ischemic heart disease or significant valvular disease.

>>Concomitant treatment with monoamine oxidase inhibitors (MAOIs), thioridazine,

or within 14 days of discontinuing treatment with MAOIs, thioridazine. Similarly,

MAOIs, thioridazine should not be administered within 7 days after Dapoxetine has been discontinued.

>>Concomitant treatment with serotonin reuptake inhibitors [selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs)] or other medicinal/herbal products with serotonergic effects or within 14 days of discontinuing treatment with these medicinal/herbal products.

SIDE EFFECTS

>>Hypertension >>Dizziness >>Headache >>Somnolence>>Tremor

USE IN PREGNANCY & LACTATION

Dapoxetine is not indicated for use by women.

Enjoy your sex time---treatment of erectile dysfunction

Sildenafil is an oral therapy for erectile dysfunction. The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine

monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum results in increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.

INDICATIONS

Indicated for the treatment of erectile dysfunction.

DOSAGE AND ADMINISTRATION

For most patients, the recommended dose of Sildenafil is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, Sildenafil may be taken anywhere from 4 hours to 0.5 hour before sexual activity. Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. The maximum recommended dosing frequency is once per day. Age >65, hepatic impairment and severe renal impairment are associated with increased plasma levels of sildenafil. A starting oral dose of 25 mg should be considered in those patients. Need to avoid high-fat meals 2 hours before taking Sildenafil.

CONTRAINDICATIONS

Sildenafil was shown to potentiate the hypotensive effects of nitrates, and its administration to patients who are using organic nitrates, either regularly and/or intermittently, in any form is therefore contraindicated. Hypersensitivity to active component.

WARNINGS & PRECAUTIONS

There is a potential for cardiac risk of sexual activity in patients with preexisting cardiovascular disease. Therefore, treatments for erectile dysfunction, including Sildenafil, should not be generally used in men for whom sexual activity is inadvisable because of their underlying cardiovascular status. Caution is advised when Sildenafil co-administered with alpha-blockers. Sildenafil and alpha-adrenergic blocking agents are both vasodilators with blood pressure lowering

effects. The concomitant administration of the protease inhibitor ritonavir substantially increases serum concentrations of sildenafil (11-fold increase in AUC). If Sildenafil is prescribed to patients taking ritonavir, caution should be used. In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. If priapism is not treated immediately, penile tissue damage and permanent loss of potency could result.

USE IN PREGNANCY AND LACTATION

Sildenafil is not indicated for use in newborns, children, or women.

SIDE EFFECTS

Headache, Flushing, Dyspepsia.