Long time sex long time enjoy---treatment of premature ejaculation

Dapoxetine is a selective serotonin reuptake inhibitor (SSRI). The mechanism of action of Dapoxetine in premature ejaculation is presumed to be linked to the inhibition of neuronal reuptakeof serotonin and the subsequent potentiation of the neurotransmitter's action at preand post-synaptic receptors.

INDICATIONS

Dapoxetine is indicated for the treatment of premature ejaculation (PE) in men 18 to 64 years of age, who have one or all of the following:

>> Persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the patient wishes.

>>Marked personal distress or interpersonal difficulty as a consequence of PE.

>>Poor control over ejaculation.

DOSAGE & ADMINISTRATION

1. Starting dose is 30 mg (approximately 1 to 3 hours prior to sexual activity).

2. Maximum recommended dose is of 60 mg.

3. Maximum dosing frequency is one dose every 24 hours.

CONTRAINDICATIONS

>>Patients with known hypersensitivity to Dapoxetine hydrochloride.

>>Patients with significant pathological cardiac conditions (such as heart failure (NYHA class II-IV), conduction abnormalities (second- or third-degree AV block or sick sinus syndrome) not treated with a permanent pacemaker, significant ischemic heart disease or significant valvular disease.

>>Concomitant treatment with monoamine oxidase inhibitors (MAOIs), thioridazine,

or within 14 days of discontinuing treatment with MAOIs, thioridazine. Similarly,

MAOIs, thioridazine should not be administered within 7 days after Dapoxetine has been discontinued.

>>Concomitant treatment with serotonin reuptake inhibitors [selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs)] or other medicinal/herbal products with serotonergic effects or within 14 days of discontinuing treatment with these medicinal/herbal products.

SIDE EFFECTS

>>Hypertension >>Dizziness >>Headache >>Somnolence>>Tremor

USE IN PREGNANCY & LACTATION

Dapoxetine is not indicated for use by women.