Online Doctor Service For Health: Long time sex long time enjoy---treatment of prema...

Online Doctor Service For Health: Long time sex long time enjoy---treatment of prema...: Dapoxetine is a selective serotonin reuptake inhibitor (SSRI). The mechanism of action of Dapoxetine in premature ejaculation is pre...

Long time sex long time enjoy---treatment of premature ejaculation

Dapoxetine is a selective serotonin reuptake inhibitor (SSRI). The mechanism of action of Dapoxetine in premature ejaculation is presumed to be linked to the inhibition of neuronal reuptakeof serotonin and the subsequent potentiation of the neurotransmitter's action at preand post-synaptic receptors.

INDICATIONS

Dapoxetine is indicated for the treatment of premature ejaculation (PE) in men 18 to 64 years of age, who have one or all of the following:

>> Persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the patient wishes.

>>Marked personal distress or interpersonal difficulty as a consequence of PE.

>>Poor control over ejaculation.

DOSAGE & ADMINISTRATION

1. Starting dose is 30 mg (approximately 1 to 3 hours prior to sexual activity).

2. Maximum recommended dose is of 60 mg.

3. Maximum dosing frequency is one dose every 24 hours.

CONTRAINDICATIONS

>>Patients with known hypersensitivity to Dapoxetine hydrochloride.

>>Patients with significant pathological cardiac conditions (such as heart failure (NYHA class II-IV), conduction abnormalities (second- or third-degree AV block or sick sinus syndrome) not treated with a permanent pacemaker, significant ischemic heart disease or significant valvular disease.

>>Concomitant treatment with monoamine oxidase inhibitors (MAOIs), thioridazine,

or within 14 days of discontinuing treatment with MAOIs, thioridazine. Similarly,

MAOIs, thioridazine should not be administered within 7 days after Dapoxetine has been discontinued.

>>Concomitant treatment with serotonin reuptake inhibitors [selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs)] or other medicinal/herbal products with serotonergic effects or within 14 days of discontinuing treatment with these medicinal/herbal products.

SIDE EFFECTS

>>Hypertension >>Dizziness >>Headache >>Somnolence>>Tremor

USE IN PREGNANCY & LACTATION

Dapoxetine is not indicated for use by women.

Enjoy your sex time---treatment of erectile dysfunction

Sildenafil is an oral therapy for erectile dysfunction. The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine

monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum results in increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.

INDICATIONS

Indicated for the treatment of erectile dysfunction.

DOSAGE AND ADMINISTRATION

For most patients, the recommended dose of Sildenafil is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, Sildenafil may be taken anywhere from 4 hours to 0.5 hour before sexual activity. Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. The maximum recommended dosing frequency is once per day. Age >65, hepatic impairment and severe renal impairment are associated with increased plasma levels of sildenafil. A starting oral dose of 25 mg should be considered in those patients. Need to avoid high-fat meals 2 hours before taking Sildenafil.

CONTRAINDICATIONS

Sildenafil was shown to potentiate the hypotensive effects of nitrates, and its administration to patients who are using organic nitrates, either regularly and/or intermittently, in any form is therefore contraindicated. Hypersensitivity to active component.

WARNINGS & PRECAUTIONS

There is a potential for cardiac risk of sexual activity in patients with preexisting cardiovascular disease. Therefore, treatments for erectile dysfunction, including Sildenafil, should not be generally used in men for whom sexual activity is inadvisable because of their underlying cardiovascular status. Caution is advised when Sildenafil co-administered with alpha-blockers. Sildenafil and alpha-adrenergic blocking agents are both vasodilators with blood pressure lowering

effects. The concomitant administration of the protease inhibitor ritonavir substantially increases serum concentrations of sildenafil (11-fold increase in AUC). If Sildenafil is prescribed to patients taking ritonavir, caution should be used. In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. If priapism is not treated immediately, penile tissue damage and permanent loss of potency could result.

USE IN PREGNANCY AND LACTATION

Sildenafil is not indicated for use in newborns, children, or women.

SIDE EFFECTS

Headache, Flushing, Dyspepsia.

Treatment of Skin and soft tissue infections& Dental infections {Clindamycin}

Clindamycin is a lincosamide antibiotic used in the treatment of infections caused by susceptible microorganisms.Clindamycin is a semisynthetic antibiotic derived from lincomycin.

Microbiology: Aerobic gram-positive cocci, including: Staphylococcus aureus, Staphylococcus epidermidis

(penicillinase and non-penicillinase producing strains), Streptococci, Pneumococci. Anaerobic gramnegative bacilli, including: Bacteroides species, Fusobacterium species. Anaerobic gram-positive non-spore forming bacilli, including: Propionibacterium species, Eubacterium species, Actinomyces species. Anaerobic and microaerophilic gram-positive cocci, including: Peptococcus species, Peptostreptococcus species,

Microaerophilic streptococci, C. perferinges

Indication: Clindamycin HCl is indicated in the treatment of the following infections caused by susceptible anaerobic bacteria or susceptible strains of gram positive bacteria such as Streptococci, Staphylococci and Pneumococci; Upper respiratory infections, Lower respiratory infections, Skin and soft tissue infections, Bone and joint infections, Pelvic infections, Intra-abdominal infections, Septicemia and endocarditis, Dental infections. As an alternative therapy when used in combination with quinine or amodiaquine for the treatment of multi-drug resistant Plasmodium falciporum infection.

Dosage and Administration: Serious infections- 150 to 300 mg every 6 hours. More severe infections- 300 to 450 mg every 6 hours. To avoid the possibility of oesophageal irritation, Clindamycin capsules should be taken with a full glass of water.

Side Effects: The adverse effects have been reported with the use of clindamycin are- abdominal pain, oesophagitis and oesophagial ulcer, nausea, vomiting and diarrhoea, pruritus, skin rashes, urticaria

Precautions: Clindamycin should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis

Contraindications: Clindamycin is contraindicated in patients previously found to be sensitive to

clindamycin or any of the ingredients of this medicine.

Pregnancy and Lactation: Pregnancy Category B. Clindamycin has been reported to appear in breast milk in the range of 0.7 to 3.8 mcg/mL. So this drug should be used only if clearly needed.

Pediatric Use: When Clindamycin HCl is administered to the pediatric population (birth to 16 years), appropriate monitoring of organ system functions is desirable.

Geriatric use: Dose adjustment of Clindamycin is not necessary

Drug Interactions: Clindamycin enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents. Antagonism has been demonstrated between clindamycin and erythromycin in vitro. Because of possible clinical significance, these two drugs should not be administered concurrently.

Overdosage: Overdosage with orally administered clindamycin has been rare. Adverse reactions similar to those seen with normal doses can be expected, however, unexpected reactions could occur. Haemodialysis and peritoneal dialysis are not effective in removing clindamycin from the serum. Overdosage should be treated with simple gastric lavage. No specific antidote is known.

Treatment of Healing of all grades of erosive esophagitis and Gastroesophageal reflux disease (GERD)

Dexlansoprazole is a proton pump inhibitor used to treat-

1. Healing of all grades of erosive esophagitis

2. Maintaining healing of erosive esophagitis

3. Heart burn associated with non-erosive Gastroesophageal reflux disease (GERD)

Dosage & administration: Dexlansoprazole capsule is administered orally. Therecommended doses of Dexlansoprazole for adults are as follows:

Indication Recommended Dose Frequency

Healing of erosive esophagitis 60 mg once daily for up to 8 weeks

Maintenance of Healed erosive esophagitis and relief of heartburn

30 mg once daily for up to 6 months Symptomatic Non-Erosive GERD 30 mg Once daily for 4 weeks

Contraindication: Dexlansoprazole is contraindicated in patients with known hypersensitivity to any component of the formulation. Hypersensitivity and anaphylaxis have been

Reported with Dexlansoprazole

Precaution: Patients taking concomitant Warfarin may require monitoring for increases in international normalized ratio (INR) and prothrombin time. Increases in INR and prothrombin time

May lead to abnormal bleeding and even death.

Side Effect: Adverse events are rarely seen; such as diarrhea, abdominal pain, nausea, vomiting, flatulence etc

Drug Interaction: Dexlansoprazole may interfere with the absorption of drugs for whichgastric pH is important for bioavailability (e.g., Ampicillin esters, Digoxin, iron salts, Ketoconazole).

Use in Pregnancy and Lactation: Dexlansoprazole is considered a pregnancy Category B medication. This means that dexlansoprazole is probably safe for use during pregnancy, although the full risks are currently unknown.

Pediatric Use: Safety and effectiveness of Dexlansoprazole in pediatric patients (less than 18 years of age) have not been established.

Geriatric Use: Safety and effectiveness of Dexlansoprazole in geriatric patients is same as Adults.

Overdose: There have been no reports of significant overdose of Dexlansoprazole. It is not expected to be removed from the circulation by hemodialysis. If an overdose occurs, treatment should be symptomatic and supportive

calcium-channel blocker with peripheral and coronary vasodilator properties{Diltiazem}

Diltiazem lowers blood

pressure and has some effect on cardiac conduction. Diltiazem interferes with the influx of calcium ions through the channels of active cell membranes.

Indication

Diltiazem is used for the prophylaxis and treatment of chronic stable (classical) and vasopastic angina pectoris and has also been used alone or in combination in the management of hypertension, also, Diltiazem is effective in myocardial infarction, coronary artery spasm, arrhythmias, Raynaud's phenomenon, oesophageal motility disorder and migraine.

Dosage & Administration

Adult: The usual dose is 60 mg thrice daily. However patient's response may vary and dosage requirements can

differ significantly between individual patients. If necessary, the divided dose may be increased to 180-00mg/day. Dosage may be started as 30 mg four times daily and increasing at 1 to 2 days intervals until the optimum response is achieved. Higher doses upto 480mg/day have been used with benefit in some patients especially in unstable angina. Elderly and patients with impaired hepatic or renal function : The recommended starting dose is 60 mg twice daily. The heart rate should be measurecfregularly and the dose should not be increased if the heart rate falls bejew 50 beats per minute.

Children: Not recommended.

Side-effect

With Diltiazem headache, ankle oedema, hypertension, dizziness, flushing, rashes (toxic erythema), nausea and Gl disturbances may occur. Transient elevation in liver enzyme values and occasionally hepatitis have been reported. Diltiazem may depress cardiac conduction and has occasionally led to AV block, bradycardia and rarely asystole or sinus

arrest. Contraindication Diltiazem is contraindicated to the patients of severe bradycardia, sick sinus syndrome, pregnancy, second or third degree AV block.

Treatment of conditions associated with gastrointestinal spasm{Hyoscme Butylbromide}

Hyoscine butylbromide is a quaternary ammonium antimuscarinic agent. Hyoscine butylbromide does not readily pass the blood-brain barrier. It is a competitive antagonist of the actions of acetylcholine and other muscarinic agonists.

Indications:Hyoscine butylbromide is used in the treatment of conditions associated with gastrointestinal spasm.

Contraindications:Hypersensitivity to Hyoscine butylbromide. Patients with prostatic enlargement, paralytic ileus or pyloric stenosis. It should not be given to patients with myasthenia gravis, unless it is to reduce the adverse muscarinic effects of an anticholinesterase agent. It should be given with caution to pregnant and lactating mothers as safety has not yet been established. It has been stated to cross the placenta.

Dosage and administration:The usual dose is 20 mg intramuscular or intravenous, repeated after 30 minutes, if necessary.

Use in pregnancy and lactation:

Enter post entire body he rCertain medications shouldn't be utilized throughout being pregnant or even nursing. Nevertheless, additional medications might be properly utilized in being pregnant or even nursing supplying the advantages towards the mom outweigh the actual dangers towards the developing fetus. Usually notify your physician if you're expecting or even planning for a being pregnant, prior to utilizing any kind of medication.

This particular medication isn't generally suggested with regard to make use of throughout being pregnant because it's security is not set up. It will just supply when the anticipated advantage towards the mom is actually more than any kind of feasible dangers towards the building infant, especially within the very first trimester. Look for healthcare guidance out of your physician.
It's not recognized in the event that this particular medication goes by in to breasts whole milk, even though just a small amount could be discovered because of the qualities from the medication. The actual course associated with medications this 1 goes in order to might slow up the manufacturing associated with breasts whole milk. The maker says this medication isn't suggested with regard to make use of throughout nursing. Obtain guidance out of your physician prior to getting this particular medication if you're nursing.

Side-effects and special precautions:Dryness of the mouth, with difficulty in swallowing, thirst, dilatation of the pupils with loss of accommodation and photophobia, increased intra ocular pressure, flushing and dryness of the skin, bradycardia followed by tachycardia, with palpitations and arrhythmias, urinary urgency with the inability to do so, as well as reduction in the tone and motility of the gastrointestinal tract, leading to constipation. Occasionally vomiting, giddiness and staggering may occur. Retrosternal pain may occur due to increased gastric reflux. Patients who experience drowsiness should not drive or operate machinery. Alcohol should be avoided. It has been stated that in elderly patients and patients with inpaired metabolic, liver or Kidney function, adverse central nervous system effects such as

Disorientation, delirium or somnolence has been more likely to occur. It should be used with caution in conditions characterized by tachycardia such as thyrotoxicosis, cardiac insufficiency or failure, and in cardiac surgery where it may further accelerate the heart-rate. Care is required in patients with acute myocardial infarction as ischemia and infarction may be worsened. It should be given with care to patients with hypertension.Hyoscine should be used with care in patients receiving other central depressants concomitantly, as central nervous system depression may be enhanced. The effects of antimuscarinic agents may be enhanced by drugs with antimuscarinic properties, such as amantadine,

some antihistamines, butyrophenones and phenothiazines, and antidepressants. Symptoms of overdosage:Toxic doses cause tachycardia, rapid respiration, hyperpyrexia, restlessness, confusion, excitement, impotence and hallucinations passing into delirium. A rash may appear on face and upper trunk, In severe

intoxication, depression of the central nervous system may occur with circulatory failure and respiratory failure. Quaternary ammonium anticholinergic agents usually have some ganglion blocking action, so that high doses may cause postural hypertension and impotence in toxic doses, nondepolarising neuromuscular block may be produced.

Supportive and symptomatic therapy should be given as required